Cofspan Syrup (100 ml) is a herbal medicinal preparation formulated as an expectorant and mucolytic agent. Derived from standardized dried ivy leaf extract (Hedera helix), Cofspan is clinically indicated for the symptomatic relief of acute inflammation of the respiratory tract, chronic inflammatory bronchial conditions, and productive coughs associated with excessive mucus production.
By facilitating the liquefaction of viscous bronchial secretions and widening constricted airways, Cofspan reduces the frequency and intensity of spasmodic, exhausting coughing fits without suppressing the central nervous system's cough reflex.
Active Ingredients & Mechanism of Action
Active Ingredient Profile
Dried Ivy Leaf Extract (Hedera helix): Standardized extract containing active triterpene saponins, primarily alpha-hederin and hederacoside C.
Physiological Mechanism of Action
Secretolytic & Mucolytic Effect: Alpha-hederin inhibits the endocytosis of beta-2 adrenergic receptors in bronchial smooth muscle cells. This secondary beta-2 sympathomimetic effect increases the production of pulmonary surfactant, which decreases the viscosity of thick mucus and liquefies bronchial secretions.
Secretomotor (Expectorant) Action: By reducing mucus viscosity, the active saponins enhance ciliary movement within the respiratory epithelium, accelerating the clearance of phlegm from the respiratory tract.
Bronchospasmolytic (Airway Relaxation) Effect: Increased beta-2 receptor availability promotes smooth muscle relaxation in the bronchial walls, dilating constricted airways and easing difficulty in breathing associated with bronchitis.
Key Medical Indications & Clinical Benefits
Relief of Productive Coughs: Accelerates the breakdown and expulsion of mucus, transforming a dry, non-productive irritation into a manageable productive cough.
Bronchial Smooth Muscle Relaxation: Alleviates bronchospasms, reducing chest tightness and respiratory discomfort during acute or persistent bronchitis.
Alcohol-Free & Non-Drowsy Formulation: Provides effective respiratory symptom management without causing central nervous system depression, daytime sedation, or lethargy.
Symptom Reduction in Respiratory Infections: Helps clear the upper and lower respiratory tracts, minimizing secondary tissue irritation caused by persistent coughing.
Usage Instructions & Dosage Protocol
Important: Always use the included measuring cup to ensure accurate administration. Consult a physician or pharmacist before administering to young children or if symptoms persist for more than 7 days.
Standard Dosage Guidelines
Adults and Adolescents (over 12 years of age): 5 ml to 7.5 ml, administered 3 times daily.
Children (6 to 11 years of age): 5 ml, administered 3 times daily.
Children (2 to 5 years of age): 2.5 ml, administered 3 times daily (under healthcare provider supervision).
Children under 2 years of age: Not recommended without prior medical consultation.
Administration Guidelines
Duration: Treatment duration depends on the severity of symptoms; however, administration should continue for at least one week, even in mild respiratory tract infections, to ensure full resolution.
Timing: Can be taken with or without food. Shake the bottle well before each use.
Safety Precautions, Warnings & Contraindications
Contraindications
Hypersensitivity: Known hypersensitivity or allergy to Hedera helix, plants of the Araliaceae family, or any inactive excipients in the syrup.
Infants under 2 years: Contraindicated in children under 2 years of age due to the risk of worsening respiratory symptoms associated with secretolytic agents in very small airways.
General Warnings & Precautions
Persistent Symptoms: If symptoms persist for more than one week, or if dyspnea (shortness of breath), fever, or purulent (pus-containing) sputum occurs, immediate medical evaluation is required.
Gastrointestinal Sensitivity: Individuals with sensitive stomachs or pre-existing gastric inflammation (such as gastritis or peptic ulcers) should exercise caution, as excessive saponin intake may cause mild gastrointestinal upset.
Pregnancy and Lactation: Due to insufficient safety data, use during pregnancy and breastfeeding is generally not recommended unless explicitly advised by a physician.
Drug Interactions: No adverse drug interactions have been reported to date. Cofspan can be co-administered with other treatments such as antibiotics when clinically indicated.
Product Specifications & Storage
Formulation: Liquid syrup (herbal extract).
Volume: 100 ml amber glass bottle with a calibrated dosing cup.
Excipient Profile: Free from artificial alcohol and synthetic colorants.
Storage Conditions: Store below 30°C (86°F) in a cool, dry place away from direct sunlight. Keep bottle tightly closed and out of reach of children.
Medication
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